Australian Centre for Research on Separation Science, School of Chemistry, University of Tasmania, Private Bag 75, Hobart, 7001, Australia.
Analyst. 2012 Nov 21;137(22):5179-89. doi: 10.1039/c2an35804b. Epub 2012 Sep 13.
Within recent years there has been an increase in research focused on the design and application of organic polymer monoliths in all areas of separation science. This is largely driven by the theoretical and practical benefits that these materials should be able to provide, particularly in terms of improved biocompatibility and high permeability. This review summarises recent new developments in this field with a focus on new approaches to the design and synthesis of polymeric monolithic materials for analytical separation science. This includes the use of alternative synthetic methodologies such as the development of hyper-crosslinked monoliths, preparation of hybrid materials and incorporation of nanostructures in the polymeric scaffold. New and developing approaches for the structural characterisation of monolithic columns are also included. Finally, we critically discuss the current chromatographic performances achieved with this column technology as well as where future developments in this field may be directed.
近年来，人们越来越关注有机聚合物整体柱在分离科学各个领域的设计和应用，这主要是因为这些材料应该能够提供理论和实际的优势，特别是在提高生物相容性和高渗透性方面。本文综述了该领域的最新新进展，重点介绍了分析分离科学用聚合物整体柱材料的设计和合成的新方法。这包括使用替代合成方法，如超交联整体柱的开发、杂化材料的制备以及在聚合物支架中加入纳米结构。还包括对整体柱结构特性的新的和发展中的方法。最后，我们批判性地讨论了这种柱技术目前所达到的色谱性能，以及该领域未来的发展方向。
