Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium.
Allergy. 2012 Nov;67(11):1347-56. doi: 10.1111/all.12010. Epub 2012 Sep 14.
Chronic rhinosinusitis (CRS) is a multifactorial disease of the upper airways with a high prevalence (approximately 11%) in the general population. Different immune and inflammatory mechanisms are involved in its pathogenesis. Alterations in the arachidonic acid pathway (leading to an imbalanced production of eicosanoids) have been linked to the pathophysiology of different diseases especially nasal polyposis, asthma, and aspirin-exacerbated respiratory disease. Furthermore, viral and bacterial infections have been identified as important factors amplifying the pro-inflammatory reactions in these pathologies. This review summarizes the impact of an imbalance in the eicosanoid pathway and the effect of Staphylococcus aureus enterotoxins on the regulation of the pro-inflammatory network in CRS and their translation into disease severity.
慢性鼻-鼻窦炎（CRS）是一种多因素的上呼吸道疾病，在普通人群中的患病率约为 11%。其发病机制涉及不同的免疫和炎症机制。花生四烯酸途径的改变（导致类二十烷酸的产生失衡）与不同疾病的病理生理学有关，特别是鼻息肉、哮喘和阿司匹林加重的呼吸道疾病。此外，病毒和细菌感染已被确定为加重这些疾病中促炎反应的重要因素。本综述总结了类二十烷酸途径失衡和金黄色葡萄球菌肠毒素对 CRS 中促炎网络调节的影响及其在疾病严重程度中的转化。
