Laboratory of Pathogen Host Interactions, CNRS UMR5235, Université de Montpellier, 34000 Montpellier, France.
Virulence Bactérienne et Infections Chroniques, INSERM U1047, Department of Infectious and Tropical Diseases, Université de Montpellier, 30908 Nîmes, France.
Toxins (Basel). 2021 Sep 23;13(10):677. doi: 10.3390/toxins13100677.
is a clinically important pathogen that causes a wide range of human infections, from minor skin infections to severe tissue infection and sepsis. has a high level of antibiotic resistance and is a common cause of infections in hospitals and the community. The rising prevalence of community-acquired methicillin-resistant (CA-MRSA), combined with the important severity of infections in general, has resulted in the frequent use of anti-staphylococcal antibiotics, leading to increasing resistance rates. Antibiotic-resistant continues to be a major health concern, necessitating the development of novel therapeutic strategies. uses a wide range of virulence factors, such as toxins, to develop an infection in the host. Recently, anti-virulence treatments that directly or indirectly neutralize toxins have showed promise. In this review, we provide an update on toxin pathogenic characteristics, as well as anti-toxin therapeutical strategies.
金黄色葡萄球菌是一种临床上重要的病原体，可引起广泛的人类感染，从轻微的皮肤感染到严重的组织感染和败血症。金黄色葡萄球菌具有高水平的抗生素耐药性，是医院和社区感染的常见原因。社区获得性耐甲氧西林金黄色葡萄球菌（CA-MRSA）的患病率不断上升，再加上金黄色葡萄球菌感染的严重性普遍较高，导致经常使用抗葡萄球菌抗生素，从而导致耐药率不断上升。抗生素耐药性金黄色葡萄球菌仍然是一个主要的健康问题，需要开发新的治疗策略。金黄色葡萄球菌使用多种毒力因子，如毒素，在宿主中引发感染。最近，直接或间接中和毒素的抗毒力治疗方法显示出了希望。在这篇综述中，我们提供了关于毒素发病机制特征以及抗毒素治疗策略的最新信息。
