Jacome D E, Morilla-Pastor D
Department of Medicine, Palmetto General Hospital, Florida.
Clin Electroencephalogr. 1990 Jan;21(1):31-6. doi: 10.1177/155005949002100112.
Locked-in syndrome (LIS) is a state of complete paralysis except for ocular movements in a conscious individual, normally resulting from brainstem lesions. We report three patients with acute brainstem strokes and LIS whose repeated EEG recordings exhibited an "alpha coma" pattern including an unreactive alpha rhythm to multimodal stimuli. This finding is of importance since preservation of consciousness is often difficult to ascertain in LIS and presence of unreactive alpha on unresponsive patients is normally equated with vegetative states and discards LIS. Failure to diagnose LIS results in abandonment of communication efforts with these tragically affected individuals. Alpha reactivity cannot define consciousness.
闭锁综合征（LIS）是一种意识清醒个体除眼球运动外完全瘫痪的状态，通常由脑干病变引起。我们报告了3例急性脑干卒中并发闭锁综合征的患者，其重复脑电图记录显示出“α昏迷”模式，包括对多模式刺激无反应的α节律。这一发现很重要，因为在闭锁综合征中常常难以确定意识是否存在，而无反应患者出现无反应的α波通常被等同于植物状态，从而排除闭锁综合征。未能诊断出闭锁综合征会导致放弃与这些不幸受影响个体的沟通努力。α波反应性不能定义意识。
