Junquéro D, Modat G, Coquelet C, Bonne C
Laboratoire de Physiologie Cellulaire, Université Montpellier, France.
Cornea. 1990 Jan;9(1):41-4.
Epidermal growth factor (EGF) is mitogenic for bovine corneal endothelial cells in culture. Pretreatment with either retinoic acid or the synthetic analog CBS-211 A ((E)-4-[2-(2-isopropyl-5-thienyl)propenyl]benzoic acid) at 10(-8)-10(-6) M enhanced the EGF effect. This potentiating effect of retinoids contrasts with their intrinsic activity, which results in cell growth inhibition in the absence of growth factor. The present data emphasize the previously reported beneficial effect of retinoic acid on corneal endothelium wound healing. This effect could be related to the potentiation of endogenous growth factors and further underlines the importance of retinoids in the medical treatment of corneal endothelial lesions.
表皮生长因子（EGF）对培养中的牛角膜内皮细胞具有促有丝分裂作用。用视黄酸或合成类似物CBS - 211 A（（E）-4 - [2 - （2 - 异丙基 - 5 - 噻吩基）丙烯基]苯甲酸）以10^(-8)-10^(-6) M进行预处理可增强EGF的作用。类视黄醇的这种增强作用与其内在活性形成对比，在没有生长因子的情况下，其内在活性会导致细胞生长抑制。目前的数据强调了先前报道的视黄酸对角膜内皮伤口愈合的有益作用。这种作用可能与内源性生长因子的增强有关，并进一步强调了类视黄醇在角膜内皮病变医学治疗中的重要性。
