Tauber J, Sainz de la Maza M, Hoang-Xuan T, Foster C S
Immunology Service, Massachusetts Eye & Ear Infirmary, Boston 02114.
Cornea. 1990 Jan;9(1):66-73.
We reviewed our experience in the management of 47 patients (61 eyes) with peripheral ulcerative keratitis (PUK) to establish guidelines for appropriate indications to consider institution of systemic chemotherapy. Fifty-three percent of patients had a systemic disease as the etiology of PUK; one fourth of these were newly diagnosed as a result of meticulous history taking. The histologic demonstration of vasculitis in ocular tissue was the crucial step in deciding on chemotherapy in more than half of our patients. The presence of scleritis was highly associated with active vasculitis. Twelve of 14 patients with bilateral PUK required chemotherapy. Recommendations for an approach to therapy of PUK are presented.
我们回顾了我们对47例（61只眼）周边溃疡性角膜炎（PUK）患者的治疗经验，以制定关于考虑采用全身化疗的适当指征的指南。53%的患者因全身性疾病导致PUK；其中四分之一是通过详细的病史采集新诊断出来的。眼部组织中血管炎的组织学证明是我们一半以上患者决定化疗的关键步骤。巩膜炎的存在与活动性血管炎高度相关。14例双侧PUK患者中有12例需要化疗。本文提出了PUK治疗方法的建议。
