Sangwan V S, Zafirakis P, Foster C S
Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Boston, USA.
Indian J Ophthalmol. 1997 Mar;45(1):7-17.
Mooren's ulcer is strictly a peripheral ulcerative keratitis (PUK) with no associated scleritis. It occurs completely in absence of any diagnosable systemic disorder that could be responsible for the progressive destruction of the cornea. The aetiology of Mooren's ulcer remains uncertain. However, recent studies indicate that it is an autoimmune disease directed against a specific target molecule in the corneal stroma, probably triggered in genetically susceptible individuals by one of several possible provocateurs. Advances have been made in the management of this disease. Immunosuppressive therapy has been shown increasingly successful in patients unresponsive to conventional treatment and in bilateral progressive destructive ocular disease.
蚕蚀性角膜溃疡严格来说是一种周边溃疡性角膜炎（PUK），不伴有巩膜炎。它完全在没有任何可诊断的全身性疾病的情况下发生，而这些全身性疾病可能导致角膜的进行性破坏。蚕蚀性角膜溃疡的病因仍不确定。然而，最近的研究表明，它是一种针对角膜基质中特定靶分子的自身免疫性疾病，可能由几种可能的激发因素之一在遗传易感个体中引发。这种疾病的治疗已经取得了进展。免疫抑制疗法在对传统治疗无反应的患者以及双侧进行性破坏性眼病患者中越来越成功。
