Matsumura Kenta, Noguchi Hiroko, Nishi Daisuke, Matsuoka Yutaka
Kanazawa University, Kodaira, Japan.
Glob J Health Sci. 2011 Dec 29;4(1):3-9. doi: 10.5539/gjhs.v4n1p3.
Our recent pilot study has shown that the supplementation of omega-3 fatty acids (fish oil) immediately after a traumatic event may be effective toward the secondary prevention of post-traumatic disorder (PTSD). To lay the groundwork for addressing the mechanism by which omega-3 fatty acids can prevent PTSD, we analyzed its psychophysiological data. The psychophysiological data included heart rate, skin conductance, and continuous blood pressure during patient subjection to startling tones and idiographic trauma-related cues. Of the 8 patients, 1 met the diagnostic criteria for PTSD. Compared to the seven patients without PTSD, one patient with PTSD showed relatively large reactivity to the startle tones. In contrast, this patient did not show large reactivity to the trauma-related cue during script-driven imagery. The combination of psychophysiological measurements in our randomized control trial should shed light on the underlying mechanisms by which omega-3 fatty acids can prevent PTSD.
我们最近的一项初步研究表明，在创伤事件发生后立即补充ω-3脂肪酸（鱼油）可能对创伤后应激障碍（PTSD）的二级预防有效。为了为探讨ω-3脂肪酸预防PTSD的机制奠定基础，我们分析了其心理生理学数据。心理生理学数据包括患者在受到惊吓声和个性化创伤相关线索刺激时的心率、皮肤电导率和连续血压。8名患者中，1名符合PTSD的诊断标准。与7名无PTSD的患者相比，1名患有PTSD的患者对惊吓声表现出相对较大的反应性。相比之下，该患者在脚本驱动的意象过程中对创伤相关线索未表现出较大反应性。我们随机对照试验中的心理生理学测量组合应能阐明ω-3脂肪酸预防PTSD的潜在机制。
