Lauterbach R, Pawlik D, Tomaszczyk B, Cholewa B
Neonatal Department, Jagiellonian University Medical College, Cracow, Poland.
Eur J Pediatr. 1994 Sep;153(9):672-4. doi: 10.1007/BF02190690.
Pentoxifylline (Trental, 5 mg/kg/h for 6 h) was administered to 17 premature infants with sepsis, on 3 successive days. A statistically significant decrease in mortality rate (P < 0.04) was observed in comparison to a retrospectively analysed group of 13 septic infants, who were treated in a comparative way but without the use of a pentoxifylline infusion. The suggestion that pentoxifylline may be an effective drug in the treatment of Gram-negative sepsis in premature infants should be tested in a double-blind, randomized study.
对17名患有败血症的早产儿连续3天给予己酮可可碱（曲奥舒凡，5毫克/千克/小时，持续6小时）。与一组经回顾性分析的13名败血症婴儿相比，观察到死亡率有统计学意义的下降（P < 0.04），这组婴儿接受了对比治疗，但未使用己酮可可碱输注。己酮可可碱可能是治疗早产儿革兰氏阴性败血症的有效药物这一建议，应在双盲、随机研究中进行检验。
