Ansari Saqib H, Shamsi Tahir S, Khan Mohammed Tahir, Perveen Kousar, Farzana Tasneem, Erum Sajida, Ansari Iqra
Department of Haematology, National Institute of Blood Diseases, Karachi.
J Coll Physicians Surg Pak. 2012 Sep;22(9):610-1.
The purpose of this study was to determine the frequency and trend of transfusion transmitted infections (TTI) in chronically transfused β-thalassaemia major (TM) patients with reference to the duration of transfusions. A cross-sectional study was done on 160 β-TM patients and 5517 healthy blood donors to find out the prevalence of HCV, HBV and HIV infections. Out of 160 patients, 21 cases (13.1%) were anti-HCV positive, 2 (1.25%) were HBsAg positive. HIV antibodies were not detected in any sample. However, 109 (1.9%) and 104 (1.8%) of 5517 blood donors were positive for HCV and HBV respectively. No donor showed HIV antibodies. Anti-HCV was positive in 9/111(8.4%) thalassaemics (< 10 years of age) while 11/49 (22%) [> 10 years of age] showing significant difference (p = 0.005) among the two groups. For the past 10 - 12 years the screening of blood has reduced the magnitude of the disease significantly as shown by the trend in two age groups. Further improvements need to be done to implement uniform screening throughout the country.
本研究的目的是参照输血时长，确定长期接受输血的重型β地中海贫血（TM）患者中输血传播感染（TTI）的频率和趋势。对160例β-TM患者和5517名健康献血者进行了一项横断面研究，以了解丙型肝炎病毒（HCV）、乙型肝炎病毒（HBV）和人类免疫缺陷病毒（HIV）感染的流行情况。在160例患者中，21例（13.1%）抗-HCV呈阳性，2例（1.25%）HBsAg呈阳性。所有样本均未检测到HIV抗体。然而，5517名献血者中分别有109例（1.9%）和104例（1.8%）HCV和HBV呈阳性。没有献血者检测出HIV抗体。9/111（8.4%）的地中海贫血患者（<10岁）抗-HCV呈阳性，而11/49（22%）[>10岁]，两组之间存在显著差异（p = 0.005）。在过去10 - 12年里，血液筛查显著降低了疾病的严重程度，这在两个年龄组的趋势中得到了体现。需要进一步改进，以便在全国范围内实施统一筛查。
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