Yasmeen Humaira, Hasnain Shahida
Department of Microbiology and Molecular Genetics, University of the Punjab, Quaid-e-Azam Campus, Lahore, Punjab, Pakistan; Department of Microbiology and Molecular Genetics, The Women University Multan, Punjab, Pakistan.
Department of Microbiology and Molecular Genetics, University of the Punjab, Quaid-e-Azam Campus, Lahore, Punjab, Pakistan; Department of Microbiology and Molecular Genetics, The Women University Multan, Punjab, Pakistan.
Hematol Transfus Cell Ther. 2019 Oct-Dec;41(4):316-323. doi: 10.1016/j.htct.2019.03.008. Epub 2019 Jun 28.
Blood transfusion-transmitted infections in individuals suffering from beta-thalassemia have been reported in Pakistan, but the information on their sociodemographic and clinical determinants is lacking. This study aims to describe the prevalence, as well as the factors, contributing in blood transfusion-transmitted infections.
Between December 2011 and December 2013, in a non-probable sampling, 350 thalassemia patients were recruited in Lahore, Multan, Karachi and Peshawar, Pakistan. Subjects were screened for transfusion-transmitted infections.
A seropositive rate of 36.5% was observed; males (94, 73.4%) and females (34, 26.6%). Among several risk factors associated with transfusion-transmitted infections, province (p=0.001), gender (p=0.003), age (p<0.03), education (p<0.00), degree of consanguinity (p=0.05), age at fetal blood test (p=0.005), fetal hemoglobin levels (p=0.005), death due to thalassemia (p=0.001) and iron-related complications (p=0.04) showed significant correlation. Participants with an age >10 years were significantly more prone to seropositivity than those aged ≤10 years. Moreover, the ferritin level was also significantly higher in those aged >10 years than in those ≤10 years. It was observed that males had a higher seroprevalence rate (94, 73.4%) than females (34, 26.6%). The most prevalent transfusion-transmitted infections was the hepatitis C virus, with 115 cases (89.8%).
A high prevalence rate of HCV in subjects with transfusion-dependent thalassemia is linked with insufficient facilities, poor management and compromised socioeconomic status. Therefore, more multicenter studies covering cities from different regions of the country are needed in order to develop preventive measurements at the regional and national level.
在巴基斯坦，已报告了β地中海贫血患者中输血传播感染的情况，但缺乏关于其社会人口统计学和临床决定因素的信息。本研究旨在描述输血传播感染的患病率及其影响因素。
2011年12月至2013年12月期间，在巴基斯坦拉合尔、木尔坦、卡拉奇和白沙瓦进行了非概率抽样，招募了350名地中海贫血患者。对受试者进行输血传播感染筛查。
观察到血清阳性率为36.5%；男性（94例，73.4%）和女性（34例，26.6%）。在与输血传播感染相关的几个危险因素中，省份（p = 0.001）、性别（p = 0.003）、年龄（p < 0.03）、教育程度（p < 0.00）、近亲程度（p = 0.05）、胎儿血液检测时的年龄（p = 0.005）、胎儿血红蛋白水平（p = 0.005）、因地中海贫血死亡（p = 0.001）和铁相关并发症（p = 0.04）显示出显著相关性。年龄>10岁的参与者血清阳性率显著高于年龄≤10岁的参与者。此外，年龄>10岁者的铁蛋白水平也显著高于年龄≤10岁者。观察到男性的血清流行率（94例，73.4%）高于女性（34例，26.6%）。最常见的输血传播感染是丙型肝炎病毒，有115例（89.8%）。
输血依赖型地中海贫血患者中丙型肝炎病毒的高流行率与设施不足、管理不善和社会经济地位低下有关。因此，需要开展更多覆盖该国不同地区城市的多中心研究，以便在区域和国家层面制定预防措施。
