Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Food Chem. 2012 Dec 15;135(4):2222-8. doi: 10.1016/j.foodchem.2012.07.033. Epub 2012 Jul 15.
Immunosenescence, the progressive decline of adaptive immunity and chronic inflammation with ageing has been demonstrated to be the main factor responsible for infections, cancer and autoimmune conditions in the elderly. Senescence-accelerated mouse (SAM) was used to study the protective effects of Pu-erh tea in the elderly. The senile-prone sub-strain, SAM-P8 mice were administered individually with ripened or crude Pu-erh tea at 125, 250 or 500mg/kg. The results showed that Pu-erh tea significantly increased the fractions of naïve T lymphocytes, CD8(+)CD28(+) T lymphocytes and NK cells in the peripheral blood, but decreased the levels of IL-6 in aged mice. These data suggested that the Pu-erh tea reversed the immunosenescence by restoring the immune deficiency and decreasing pro-inflammatory cytokine. Thus, long term drinking of Pu-erh tea may be beneficial for the aged population in terms of increasing the body's resistance to infection and cancer.
免疫衰老，即适应性免疫的逐渐衰退和衰老伴随的慢性炎症，已被证明是老年人感染、癌症和自身免疫性疾病的主要原因。衰老加速小鼠（SAM）被用于研究普洱茶对老年人的保护作用。易衰老亚系 SAM-P8 小鼠分别给予 125、250 或 500mg/kg 的熟普洱茶或生普洱茶。结果表明，普洱茶可显著增加老年小鼠外周血中 naïve T 淋巴细胞、CD8(+)CD28(+)T 淋巴细胞和 NK 细胞的比例，降低 IL-6 水平。这些数据表明，普洱茶通过恢复免疫缺陷和降低促炎细胞因子来逆转免疫衰老。因此，长期饮用普洱茶可能有益于老年人群，增加身体对感染和癌症的抵抗力。
