Department of Pathology and Laboratory Medicine, Spectrum Health Blodgett Campus, Grand Rapids, MI 49506, USA.
Cardiovasc Pathol. 2013 May-Jun;22(3):e1-4. doi: 10.1016/j.carpath.2012.07.007. Epub 2012 Sep 11.
Amphetamines have been reported to cause myocardial infarct, cerebral hemorrhage, aortic dissection, hypertension, vasculitis, aneurysms, and, occasionally, death from direct toxicity. To date, there have been no reports of coronary intimal hyperplasia in an amphetamine user.
A 29-year-old male was found collapsed after jogging. He had been taking amphetamines for 11 years for attention deficit/hyperactivity disorder. Past medical history was positive for mild hypertension and migraine headaches. He underwent a complete autopsy and drug screen.
At gross autopsy his left anterior descending (LAD) coronary artery was occluded and he had an old myocardial infarct in the anterior wall of the left ventricle. Microscopic findings included occlusive intimal hyperplasia (positive for smooth muscle actin) in the LAD and an old left ventricular anterior wall infarct surrounded by acute infarct.
In addition to other reported adverse effects, amphetamines can also cause occlusive intimal hyperplasia of the coronary arteries.
安非他命已被报道可导致心肌梗死、脑出血、主动脉夹层、高血压、血管炎、动脉瘤，并且偶尔可因直接毒性导致死亡。迄今为止，尚无安非他命使用者发生冠状动脉内膜增生的报告。
一名 29 岁男性在慢跑后昏倒，他因注意力缺陷/多动障碍已服用安非他命 11 年。既往病史为轻度高血压和偏头痛。他接受了全面尸检和药物筛查。
大体解剖发现他的左前降支（LAD）冠状动脉闭塞，左心室前壁有陈旧性心肌梗死。显微镜检查结果包括 LAD 的闭塞性内膜增生（平滑肌肌动蛋白阳性）和左心室前壁陈旧性梗死周围的急性梗死。
除其他已报道的不良反应外，安非他命还可导致冠状动脉闭塞性内膜增生。
