DNA 修复基因 ERCC5 多态性与口腔鳞状细胞癌的关系。
Association between polymorphisms of DNA repair gene ERCC5 and oral squamous cell carcinoma.
机构信息
College of Dental Medicine, Columbia University, New York, New York, USA.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Nov;114(5):624-9. doi: 10.1016/j.oooo.2012.05.013. Epub 2012 Sep 12.
OBJECTIVE
Short nucleotide polymorphism in ERCC5 (rs751402), a key molecule in DNA damage repair, was analyzed in 575 individuals who were either control subjects with no clinical evidence of malignant transformation of the oral mucosa or subjects with oral squamous cell carcinoma (OSCC).
STUDY DESIGN
All participants provided a blood sample, demographic data, and information on habitual use of tobacco, alcohol, and areca nut.
RESULTS
rs751402 homozygocity for C allele was found to confer a statistically significant protection against OSCC (adjusted odds ratio 0.56, 95% confidence interval 0.35-0.89; P = .01), whereas rs751402 T alleles were associated with increased risk.
CONCLUSIONS
Our findings suggest that there is an association between rs751402 polymorphism and incidence of oral cancer. ERCC rs751402 CC genotype is significantly associated with decreased risk of OSCC, whereas the T allotype is correlated with higher risk of OSCC.
目的
分析 ERCC5（rs751402）中短核苷酸多态性，该基因是 DNA 损伤修复的关键分子，在 575 名个体中进行了分析，这些个体要么是没有口腔黏膜恶性转化临床证据的对照受试者，要么是口腔鳞状细胞癌（OSCC）受试者。
研究设计
所有参与者均提供了血液样本、人口统计学数据以及关于习惯性使用烟草、酒精和槟榔的数据。
结果
发现 rs751402 等位基因 C 纯合子对 OSCC 具有统计学显著的保护作用（调整后的优势比为 0.56，95%置信区间为 0.35-0.89；P =.01），而 rs751402 T 等位基因则与风险增加相关。
结论
我们的研究结果表明，rs751402 多态性与口腔癌的发生之间存在关联。ERCC rs751402 CC 基因型与 OSCC 风险降低显著相关，而 T 等位基因与 OSCC 风险升高相关。
Zotero 插件