Yoon Angela J, Kuo Wu-Hsien, Lin Chiao-Wen, Yang Shun-Fa
College of Dental Medicine, Columbia University, New York City, NY, USA.
Oncol Lett. 2011 Sep 1;2(5):911-914. doi: 10.3892/ol.2011.325. Epub 2011 Jun 10.
Excision repair cross‑complementing rodent repair deficiency, complementation group 5 (ERCC5, XPG) is a key molecule in DNA damage repair. We analyzed the contribution of ERCC5 rs751402 polymorphism in increased susceptibility to hepatocellular carcinoma (HCC). A total of 96 patients diagnosed with HCC and 336 healthy controls provided blood samples for analysis of rs751402 genotypes. Demographic data and information on habitual use of tobacco and alcohol were collected. After adjusting for covariates, rs751402 homozygocity for allele C was found to confer a statistically significant protection [adjusted odds ratio (AOR)=0.56; 95% CI, 0.35‑0.89; p=0.01] against HCC, whereas rs751402 T alleles were associated with increased risk (AOR=1.69; 95% CI, 0.74‑3.87). Individuals with the inherited ERCC rs751402 CC genotype may experience significant protection against HCC, whereas individuals with T alleles appear to be exposed to higher risk.
切除修复交叉互补啮齿动物修复缺陷互补组5（ERCC5，XPG）是DNA损伤修复中的关键分子。我们分析了ERCC5 rs751402多态性在肝细胞癌（HCC）易感性增加中的作用。共有96例诊断为HCC的患者和336例健康对照者提供血样用于rs751402基因型分析。收集了人口统计学数据以及烟草和酒精使用习惯的信息。在对协变量进行校正后，发现等位基因C的rs751402纯合性对HCC具有统计学意义的保护作用[校正比值比（AOR）=0.56；95%可信区间（CI），0.35 - 0.89；p = 0.01]，而rs751402 T等位基因与风险增加相关（AOR = 1.69；95% CI，0.74 - 3.87）。具有遗传性ERCC rs751402 CC基因型的个体可能对HCC有显著的保护作用，而具有T等位基因的个体似乎面临更高的风险。
