Ruck Richard C, Eberly Matthew D
Department of Pediatric Infectious Diseases, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, United States.
Int J Pediatr Otorhinolaryngol. 2012 Dec;76(12):1849-51. doi: 10.1016/j.ijporl.2012.08.018. Epub 2012 Sep 13.
Acute mastoiditis is a potential complication of acute otitis media (AOM), with Streptococcus pneumoniae historically the most common pathogen isolated. Following the release of the 7-valent pneumococcal conjugate vaccine in 2000, a marked decline in invasive pneumococcal disease and a smaller reduction in pneumococcal AOM were observed, but data regarding its impact on acute mastoiditis are limited. With the recent introduction of the 13-valent pneumococcal conjugate vaccine (PCV13), it is anticipated that pneumococcal AOM and invasive disease will further diminish. We report a case of acute mastoiditis from a multidrug-resistant serotype 19A S. pneumoniae in an immunocompetent child who had received three PCV13 vaccinations.
急性乳突炎是急性中耳炎（AOM）的一种潜在并发症，历史上肺炎链球菌是分离出的最常见病原体。2000年7价肺炎球菌结合疫苗发布后，侵袭性肺炎球菌病显著下降，肺炎球菌性AOM也有较小幅度的减少，但关于其对急性乳突炎影响的数据有限。随着近期13价肺炎球菌结合疫苗（PCV13）的引入，预计肺炎球菌性AOM和侵袭性疾病将进一步减少。我们报告一例由多重耐药的19A血清型肺炎链球菌引起的急性乳突炎病例，该病例发生在一名已接种3剂PCV13疫苗的免疫功能正常儿童身上。
