Per Hüseyin, Canpolat Mehmet, Gümüş Hakan, Poyrazoğlu Hatice Gamze, Yıkılmaz Ali, Karaküçük Sarper, Doğan Hakkı, Kumandaş Sefer
Erciyes University, Faculty of Medicine, Department of Pediatrics, Division of Pediatric Neurology, Kayseri, Turkey.
Brain Dev. 2013 Jun;35(6):561-8. doi: 10.1016/j.braindev.2012.08.008. Epub 2012 Sep 13.
Pseudotumor cerebri (PTC) is a clinical condition characterized by signs and symptoms of increased intracranial pressure, such as headache and papilledema. Our aim was to investigate the etiological and clinical features of pseudotumor cerebri (PTC) in children.
We performed a comprehensive analysis of epidemiology, diagnostic work-up, therapy, and clinical follow-up in 42 consecutive patients.
Totally 42 patients diagnosed with PTC [27 (64.3%) females and 15 (35.7%) males] were included in the study. The average age of the symptoms onset was 10.79±3.43 years (range from 12 months to 17 years). Obesity was found in eleven (26.2%) of them. Two of the patients had familial mediterranean fever, two of them had posttraumatic PTC. The following diseases were one patient, respectively; mycophenolate mofetil-induced PTC, hypervitaminosis A induced PTC, corticosteroid induced withdrawal due to nephritic syndrome, use of oral contraceptives, Guillain-Barre syndrome, urinary tract infection, varicella-zoster virus infection and dural venous sinus thrombosis associated with otitis media. The most common symptom was headache, recorded in 76.2% of the patients. All patients were treated medically. Three patients in our group also required a ventriculoperitoneal shunt.
Pseudotumor cerebri is an avoidable cause of visual loss, both in adults and children. Pre-pubertal obese girls are more common. Medical therapy appeared to be successful in treating pediatric PTC in most patients. Nevertheless, despite adequate treatment, children can rarely experience loss of visual field and acuity; thus, prompt diagnosis and management are important.
假性脑瘤（PTC）是一种以颅内压升高的体征和症状为特征的临床病症，如头痛和视乳头水肿。我们的目的是研究儿童假性脑瘤（PTC）的病因和临床特征。
我们对42例连续患者的流行病学、诊断检查、治疗及临床随访进行了综合分析。
本研究共纳入42例诊断为PTC的患者[27例（64.3%）为女性，15例（35.7%）为男性]。症状出现的平均年龄为10.79±3.43岁（范围从12个月至17岁）。其中11例（26.2%）患者肥胖。2例患者患有家族性地中海热，2例患有创伤后PTC。以下疾病各有1例患者；霉酚酸酯诱导的PTC、维生素A过多症诱导的PTC、因肾病综合征导致的皮质类固醇撤药、口服避孕药的使用、格林-巴利综合征、尿路感染、水痘-带状疱疹病毒感染以及与中耳炎相关的硬脑膜静脉窦血栓形成。最常见的症状是头痛，76.2%的患者有此症状。所有患者均接受了药物治疗。我们组中有3例患者还需要进行脑室腹腔分流术。
假性脑瘤是成人和儿童视力丧失的一个可避免原因。青春期前肥胖女孩更为常见。药物治疗在大多数儿童PTC患者中似乎是成功的。然而，尽管进行了充分治疗，儿童仍很少会出现视野和视力丧失；因此，及时诊断和处理很重要。
