Department of Basic Sciences, Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92354, United States.
Cytokine Growth Factor Rev. 2012 Dec;23(6):323-31. doi: 10.1016/j.cytogfr.2012.08.004. Epub 2012 Sep 14.
Interleukin 24 (mda-7/IL-24) has been classified as an anti-cancer gene for its ability to selectively induce cell death in cancer cells while having little to no effect on normal cells. Although the exact mechanisms by which IL-24 functions have not been completely elucidated, several pathways have consistently been identified: endoplasmic reticulum stress, ceramide-mediated events, and the generation of reactive oxygen species. In addition to these mechanistic analyses, significant progress has also been reported regarding the clinical potential of this anti-cancer gene. For example, many groups are utilizing mda-7/IL-24 in combination with other cancer therapies. This review examines the current research and potential future of this important anti-cancer gene.
白细胞介素 24（mda-7/IL-24）因其能够选择性地诱导癌细胞死亡而被归类为抗癌基因，而对正常细胞几乎没有影响。尽管 IL-24 的作用确切机制尚未完全阐明，但已经确定了几种途径：内质网应激、神经酰胺介导的事件和活性氧的产生。除了这些机制分析外，关于这种抗癌基因的临床潜力也有重大进展的报道。例如，许多小组正在利用 mda-7/IL-24 与其他癌症疗法结合使用。本综述检查了这种重要抗癌基因的当前研究和潜在未来。
