Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:58-66. doi: 10.1016/j.prostaglandins.2012.08.006. Epub 2012 Sep 3.
Prostanoids play pivotal roles in inflammation and pain. Cyclooxygenase (COX) inhibitors, the nonsteroidal anti-inflammatory drugs (NSAIDs), depress prostanoid formation and are widely used to treat inflammatory pain. However, their therapeutic benefit is offset by serious side-effects, primarily gastrointestinal and cardiovascular complications. Pathway elements downstream of the COX enzymes, particularly the terminal synthases and receptors of prostaglandin E2, have been proposed as alternative targets for the development of novel NSAID like drugs. Here, we summarize the current knowledge on the roles of individual prostanoids in modulating inflammatory pain.
前列腺素在炎症和疼痛中发挥关键作用。环氧化酶 (COX) 抑制剂，即非甾体类抗炎药 (NSAIDs)，可抑制前列腺素的形成，被广泛用于治疗炎症性疼痛。然而，其治疗益处被严重的副作用抵消，主要是胃肠道和心血管并发症。COX 酶下游的途径元素，特别是前列腺素 E2 的末端合成酶和受体，已被提议作为开发新型 NSAID 样药物的替代靶标。在这里，我们总结了关于个别前列腺素在调节炎症性疼痛中的作用的现有知识。
