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成年马非甾体抗炎药的临床药理学与治疗评估

The Clinical Pharmacology and Therapeutic Evaluation of Non-Steroidal Anti-Inflammatory Drugs in Adult Horses.

作者信息

Mercer Melissa A, Davis Jennifer L, McKenzie Harold C

机构信息

Department of Biological Sciences and Pathobiology, Virginia Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA.

Department of Large Animal Clinical Sciences, Virginia Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA.

出版信息

Animals (Basel). 2023 May 10;13(10):1597. doi: 10.3390/ani13101597.

DOI:10.3390/ani13101597
PMID:37238029
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10215112/
Abstract

This review firstly examines the underlying pathophysiology of pain and inflammation associated with orthopedic disease and endotoxemia. Then, it reviews the clinical pharmacology (pharmacokinetics and pharmacodynamics) of both conventional and non-conventional NSAIDs in the adult horse, and finally provides an overview of different modalities to evaluate the therapeutic efficacy of NSAIDs in research.

摘要

本综述首先探讨与骨科疾病和内毒素血症相关的疼痛和炎症的潜在病理生理学。然后，回顾成年马体内传统和非传统非甾体抗炎药的临床药理学（药代动力学和药效学），最后概述在研究中评估非甾体抗炎药治疗效果的不同方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d7/10215112/340ab235ff8a/animals-13-01597-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d7/10215112/340ab235ff8a/animals-13-01597-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d7/10215112/340ab235ff8a/animals-13-01597-g001.jpg

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本文引用的文献

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Pharmacokinetics, clinical efficacy and safety of acetaminophen (paracetamol) in adult horses with naturally occurring chronic lameness.在自然发生慢性跛行的成年马中，对乙酰氨基酚（扑热息痛）的药代动力学、临床疗效和安全性。
Equine Vet J. 2024 Jan;56(1):202-214. doi: 10.1111/evj.13959. Epub 2023 Jun 7.
2
Ocular penetration of oral acetaminophen in horses.口服对乙酰氨基酚在马眼中的穿透性。
Equine Vet J. 2023 Sep;55(5):899-904. doi: 10.1111/evj.13902. Epub 2022 Dec 14.
3
The ongoing quest for a validated, universally accepted visual lameness grading scale.
Administration of sodium hyaluronate to adult horses prior to and immediately after exercise does not alter the range of motion in either the tarsus or metacarpophalangeal joints.
在成年马运动前及运动后立即给予透明质酸钠，不会改变跗关节或掌指关节的活动范围。
Transl Anim Sci. 2024 Nov 2;8:txae153. doi: 10.1093/tas/txae153. eCollection 2024.
4
Improved quality of life and pain relief in mature horses with osteoarthritis after oral transmucosal cannabidiol oil administration as part of an analgesic regimen.作为镇痛方案的一部分，口服经粘膜大麻二酚油后，患有骨关节炎的成年马匹的生活质量得到改善，疼痛得到缓解。
Front Vet Sci. 2024 Feb 6;11:1341396. doi: 10.3389/fvets.2024.1341396. eCollection 2024.
5
Analgesic Efficacy of Non-Steroidal Anti-Inflammatory Drug Therapy in Horses with Abdominal Pain: A Systematic Review.非甾体抗炎药治疗腹痛马匹的镇痛效果：一项系统评价
Animals (Basel). 2023 Nov 8;13(22):3447. doi: 10.3390/ani13223447.
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Equine Vet J. 2023 Jan;55(1):5-8. doi: 10.1111/evj.13896. Epub 2022 Nov 16.
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J Am Vet Med Assoc. 2022 Oct 4;260(15):1963-1966. doi: 10.2460/javma.22.08.0367.
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Equine Vet J. 2023 Jan;55(1):69-77. doi: 10.1111/evj.13564. Epub 2022 Feb 23.
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Pain severity scores for common equine disorders as provided by horse owners and equine veterinarians.马主和兽医提供的常见马科动物疾病疼痛严重程度评分。
Equine Vet J. 2022 Nov;54(6):1094-1102. doi: 10.1111/evj.13559. Epub 2022 Feb 7.