细胞因子白细胞介素 27 和干扰素-γ 促进了限制感染诱导病理所需的不同 Treg 细胞群体。
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
机构信息
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Immunity. 2012 Sep 21;37(3):511-23. doi: 10.1016/j.immuni.2012.06.014. Epub 2012 Sep 13.
Abstract
Interferon-γ (IFN-γ) promotes a population of T-bet(+) CXCR3(+) regulatory T (Treg) cells that limit T helper 1 (Th1) cell-mediated pathology. Our studies demonstrate that interleukin-27 (IL-27) also promoted expression of T-bet and CXCR3 in Treg cells. During infection with Toxoplasma gondii, a similar population emerged that limited T cell responses and was dependent on IFN-γ in the periphery but on IL-27 at mucosal sites. Transfer of Treg cells ameliorated the infection-induced pathology observed in Il27(-/-) mice, and this was dependent on their ability to produce IL-10. Microarray analysis revealed that Treg cells exposed to either IFN-γ or IL-27 have distinct transcriptional profiles. Thus, IFN-γ and IL-27 have different roles in Treg cell biology and IL-27 is a key cytokine that promotes the development of Treg cells specialized to control Th1 cell-mediated immunity at local sites of inflammation.
摘要
干扰素-γ（IFN-γ）促进 T 细胞特异性转录因子（T-bet）+ CXCR3+调节性 T（Treg）细胞的产生，从而限制 T 辅助 1（Th1）细胞介导的病理。我们的研究表明，白细胞介素-27（IL-27）也促进了 Treg 细胞中 T-bet 和 CXCR3 的表达。在感染刚地弓形虫时，出现了一种类似的细胞群，它限制了 T 细胞的反应，在外周依赖于 IFN-γ，但在黏膜部位依赖于 IL-27。Treg 细胞的转移改善了在 Il27(-/-)小鼠中观察到的感染诱导的病理，这依赖于它们产生 IL-10 的能力。微阵列分析显示，暴露于 IFN-γ或 IL-27 的 Treg 细胞具有不同的转录谱。因此，IFN-γ 和 IL-27 在 Treg 细胞生物学中具有不同的作用，IL-27 是一种关键细胞因子，它促进了专门在炎症局部部位控制 Th1 细胞介导免疫的 Treg 细胞的发育。
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