Division of Virology, National Institute of Cholera and Enteric Diseases, P-33 CIT Road Scheme XM, Beliaghata, Kolkata 700 010, West Bengal, India.
Infect Genet Evol. 2012 Dec;12(8):1933-7. doi: 10.1016/j.meegid.2012.08.009. Epub 2012 Sep 6.
During an ongoing surveillance for diarrheal pathogens, an unusual human group A rotavirus strain G3P[10] (RVA/Human-wt/IND/mcs60/2011/G3P[10]) was detected in a stool sample of a 14 months old girl child with acute diarrhea in Kolkata, eastern India. The VP7 nucleotide sequence of this strain revealed a close phylogenetic relationship to the prototype G3 strain AU-1 and Australian feline strain Cat2, whereas, the VP4 gene segment was closely related to the G8P[10] rotavirus 69M from Indonesia. Analysis of 11 gene segments of this unusual G3P[10] strain demonstrates a complex evolutionary pattern, with genes possibly derived from the group A rotaviruses of human DS-1-like and AU-1-like strains of simian and caprine host species. To our knowledge, this is the first complete genotyping report of any G3P[10] rotavirus, worldwide.
在对腹泻病原体进行的持续监测中，在印度东部加尔各答一名 14 个月大的急性腹泻女婴的粪便样本中检测到一种不寻常的人 A 群轮状病毒 G3P[10]（RVA/Human-wt/IND/mcs60/2011/G3P[10]）。该毒株的 VP7 核苷酸序列与原型 G3 株 AU-1 和澳大利亚猫科动物株 Cat2 密切相关，而 VP4 基因片段与印度尼西亚的 G8P[10]轮状病毒 69M 密切相关。对这种不寻常的 G3P[10]毒株的 11 个基因片段的分析表明，其具有复杂的进化模式，这些基因可能来自人源 DS-1 样和 AU-1 样株以及猴和山羊宿主的 A 群轮状病毒。据我们所知，这是全球首例 G3P[10]轮状病毒的完整基因分型报告。
