Dipartimento di Fisiologia Umana, Università degli studi di Milano, Milan, Italy.
Respir Physiol Neurobiol. 2013 Jan 15;185(2):369-73. doi: 10.1016/j.resp.2012.09.003. Epub 2012 Sep 13.
Coefficient of kinetic friction (μ) of pleural mesothelium blotted with filter paper, and rewetted with Ringer solution markedly increases; this increase is removed if a sufficient amount of sialomucin or hyaluronan is added to Ringer (Bodega et al., 2012. Respiratory Physiology and Neurobiology 180, 34-39). In this research we found that μ of pleural mesothelium blotted, rewetted, and sliding at physiological velocities and loads, decreased with increase of velocity, mainly at low velocities. Despite this decrease, μ at highest velocity was still double that before blotting. With small concentration of sialomucin or hyaluronan μ was markedly smaller at each velocity, decreased less with increase of velocity, and at highest velocity approached preblotting value. These findings indicate a regime of mixed lubrication in post-blotting Ringer, at variance with boundary lubrication occurring before blotting or postblotting with sufficient macromolecule addition. Greater roughness of mesothelial surface, caused by blotting, likely induces zones of elastohydrodynamic lubrication, which increase with velocity, while contact area decreases.
用滤纸吸干胸膜间皮并重新用林格溶液润湿后，其动摩擦系数（μ）明显增加；如果向林格氏液中添加足够量的唾液黏蛋白或透明质酸，则可以消除这种增加（Bodega 等人，2012 年。呼吸生理学与神经生物学，180，34-39）。在这项研究中，我们发现，在生理速度和负荷下吸干、重新润湿和滑动的胸膜间皮的μ随着速度的增加而减小，主要是在低速度下。尽管有这种减少，但在最高速度下的μ仍然是吸干前的两倍。随着唾液黏蛋白或透明质酸浓度的降低，μ在每个速度下都明显更小，随着速度的增加而减少得更少，并且在最高速度下接近吸干前的值。这些发现表明，在吸干后的林格氏液中存在混合润滑状态，这与吸干前的边界润滑或在添加足够大分子后发生的边界润滑不同。由于吸干引起的间皮表面粗糙度增加，可能会产生弹流润滑区，这些区域随着速度的增加而增加，而接触面积减小。
