School of Social & Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Clifton, Bristol BS8 2BN, United Kingdom.
Infant Behav Dev. 2012 Dec;35(4):613-26. doi: 10.1016/j.infbeh.2012.07.020. Epub 2012 Sep 12.
Both prenatal and postnatal maternal depression are independently associated with an increased risk of adverse infant development. The impact of postnatal depression on infants may be mediated through the effect of depression in reducing maternal responsiveness. However, the mechanisms underlying the effect of prenatal depression are unclear. Using longitudinal data from over 900 mother-infant pairs in a UK birth cohort (ALSPAC), we found that women with high depressive symptom scores during mid pregnancy, but NOT when their infants were 8 months, had a 30% increased risk of low maternal responsiveness when the infant was 12 months compared to women with consistently low depression. This may provide a mechanism to explain the independent association between prenatal depression and poorer infant development.
产前和产后的母亲抑郁都与婴儿发育不良的风险增加有关。产后抑郁对婴儿的影响可能是通过抑郁降低母亲反应能力的影响来介导的。然而，产前抑郁影响的机制尚不清楚。我们使用来自英国出生队列（ALSPAC）的 900 多对母婴纵向数据发现，与一直抑郁程度低的女性相比，在妊娠中期抑郁症状评分较高但婴儿 8 个月时没有这种情况的女性，其在婴儿 12 个月时的低母亲反应性风险增加了 30%。这可能为解释产前抑郁与婴儿发育较差之间的独立关联提供了一种机制。
