Speech, Language, and Hearing Sciences Department, University of Connecticut, 850 Bolton Road, Storrs, CT 06269-1085, USA.
Neuropsychologia. 2012 Dec;50(14):3564-72. doi: 10.1016/j.neuropsychologia.2012.09.005. Epub 2012 Sep 11.
Individuals with damage to the prefrontal cortex, and the dorsolateral prefrontal cortex (DLPFC) in particular, often demonstrate difficulties with the formulation of complex language not attributable to aphasia. The present study employed a discourse analysis procedure to characterize the language of individuals with left (L) or right (R) DLPFC lesions. All participants were 30-35 years post-onset of injury and presented with persistent discourse impairments. The discourse performance of the R DLPFC group was not significantly different from either the L DLPFC group or the non-injured comparison group. Individuals from the L DLPFC group demonstrated specific difficulties with narrative coherence and inclusion of critical story components. Both measures were significantly different from the comparison group. The discourse ability of the DLPFC groups was significantly correlated with measures of working memory. Findings support the use of discourse analysis for examining language impairments in individuals with PFC lesions.
前额叶皮质损伤，尤其是背外侧前额叶皮质（DLPFC）损伤的个体，通常表现出难以用语言表达复杂内容的困难，而这种困难不能归因于失语症。本研究采用话语分析程序来描述左（L）或右（R）DLPFC 损伤个体的语言。所有参与者在损伤后 30-35 年均有持续性的话语障碍。R DLPFC 组的话语表现与 L DLPFC 组或未受伤的对照组无显著差异。来自 L DLPFC 组的个体在叙述连贯性和关键故事成分的纳入方面表现出特定的困难。这两个指标均与对照组有显著差异。DLPFC 组的话语能力与工作记忆的测量显著相关。这些发现支持使用话语分析来检查前额叶皮质损伤个体的语言障碍。
