Stehr Matthias, Elamin Ayssar A, Singh Mahavir
Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, Braunschweig, Germany.
Microbes Infect. 2012 Nov;14(13):1227-37. doi: 10.1016/j.micinf.2012.08.001. Epub 2012 Aug 30.
Lipid inclusions play an important role in several pathological processes. Intracellular bacterial pathogens, such as members of the Mycobacterium and Chlamydia species are able to trigger the formation of lipid-laden foamy macrophages. Lipid droplet accumulation in the host constitutes a reservoir used by the bacilli for long-term persistence. Viruses need lipid droplets as assembly platform. We present the current knowledge about structural, functional and regulatory aspects of lipid inclusions.
脂质包涵体在多种病理过程中发挥重要作用。细胞内细菌病原体，如分枝杆菌属和衣原体属的成员，能够引发富含脂质的泡沫巨噬细胞的形成。宿主细胞中脂质滴的积累构成了细菌长期存活所利用的储存库。病毒需要脂质滴作为组装平台。我们介绍了有关脂质包涵体的结构、功能和调控方面的现有知识。
