Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON Canada.
Cell Adh Migr. 2012 Jul-Aug;6(4):319-26. doi: 10.4161/cam.20879. Epub 2012 Jul 1.
In the past year, three papers have been published exploring the role of the matricellular protein periostin in excisional skin repair. These papers all show a delay in wound closure and the kinetics of this delay are strikingly similar across the three reports. The similarities between these papers end, however, when each investigates the mechanism through which periostin influences skin repair. Three proposed mechanisms have been identified: (1) myofibroblast differentiation, (2) keratinocyte proliferation and (3) fibroblast proliferation and migration. The aim of this commentary is to compare and contrast the three studies performed to date in an attempt to decipher the role of periostin in the repair of full-thickness skin wounds.
在过去的一年中，已经发表了三篇探讨细胞外基质蛋白骨桥蛋白在切创皮肤修复中的作用的论文。这三篇论文都表明伤口闭合延迟，而且这种延迟的动力学在这三篇报告中惊人地相似。然而，当每一篇论文都在研究骨桥蛋白影响皮肤修复的机制时，这些论文之间的相似之处就结束了。已经确定了三种可能的机制：（1）肌成纤维细胞分化，（2）角质形成细胞增殖，以及（3）成纤维细胞增殖和迁移。本评论的目的是比较和对比迄今为止进行的三项研究，试图阐明骨桥蛋白在全厚皮肤伤口修复中的作用。
