Ağırgöl Şenay, Çaytemel Ceyda, Ünlü Burak, Çetinkaya Elif, Cayhan Baran, Çalım Begüm, Türkoğlu Zafer
Istanbul Çam and Sakura City Hospital, Department of Dermatology and Venereology, Istanbul, Turkey.
Istanbul Çam and Sakura City Hospital, Department of Pathology, Istanbul, Turkey.
Dermatol Pract Concept. 2025 Apr 1;15(2):4813. doi: 10.5826/dpc.1502a4813.
Lichen planopilaris (LPP) is the most prevalent form of scarring alopecia and lymphocytic infiltration that affects the infundibulum and isthmus, perifollicular melanophages, and perifollicular constrictive fibrosis OBJECTIVE: We aimed to assess the contribution of periostin tissue levels to the pathogenesis of LPP and its association with disease severity.
A total of 30 cases diagnosed with LPP between July 15 and October 15, 2022 were studied. Patient age, disease duration, disease severity, and periostin levels were recorded, and periostin immunohistochemistry was performed to obtain histoscores for the perifollicular area, dermoepidermal junction, fibroblasts, and inflammatory cells, and these were compared with the control group.
The female sex predominated, with the majority (67%); 25 patients were classified with mild disease and five with severe LPP. Statistically significant differences were found in keratinocyte staining intensities between the mild and severe groups (P=0.023; P<0.01), with the LPP group exhibiting a higher rate of moderate staining intensity compared to the control group. In terms of perifollicular staining intensities, the rate of non-staining was higher in the control group compared to the LPP group. Statistically significant differences were also observed in fibroblast (P=0.001) and inflammatory cell (P=0.001) staining intensities between the groups. No statistically significant difference was found between the patients with mild or severe disease in the LPP group.
The relationship between periostin and disease severity could not be conclusively established. The presence of periostin staining in all histopathologically-affected areas of patients with LPP suggests that periostin may serve as a promising marker in LPP.
扁平苔藓性毛发角化病（LPP）是瘢痕性脱发最常见的形式，其特征为淋巴细胞浸润，累及毛囊漏斗部和峡部、毛囊周黑素细胞及毛囊周缩窄性纤维化。目的：我们旨在评估骨膜蛋白组织水平在LPP发病机制中的作用及其与疾病严重程度的关联。
对2022年7月15日至10月15日期间诊断为LPP的30例患者进行研究。记录患者年龄、病程、疾病严重程度和骨膜蛋白水平，进行骨膜蛋白免疫组化以获取毛囊周区域、真皮表皮交界处、成纤维细胞和炎性细胞的组织学评分，并与对照组进行比较。
女性占多数（67%）；25例患者为轻度疾病，5例为重度LPP。轻度和重度组角质形成细胞染色强度存在统计学显著差异（P = 0.023；P < 0.01），与对照组相比，LPP组中度染色强度的比例更高。在毛囊周染色强度方面，对照组无染色的比例高于LPP组。两组之间成纤维细胞（P = 0.001）和炎性细胞（P = 0.001）染色强度也存在统计学显著差异。LPP组轻度或重度疾病患者之间未发现统计学显著差异。
骨膜蛋白与疾病严重程度之间的关系尚无定论。LPP患者所有组织病理学受累区域均存在骨膜蛋白染色，提示骨膜蛋白可能是LPP中有前景的标志物。
