以 AKAP150-PP2B-锚定蛋白为导向，驶向葡萄糖稳态。
Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor.
机构信息
Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
EMBO J. 2012 Oct 17;31(20):3956-7. doi: 10.1038/emboj.2012.265. Epub 2012 Sep 14.
Abstract
Glucose-stimulated insulin secretion, controlled by multiple protein phosphorylation events, is critical for the regulation of glucose homeostasis. Protein kinase A (PKA) is known to play a role in β cell physiology, but the role of its anchoring protein is not fully understood. Hinke et al (2012) illustrate the significance of A-kinase anchoring protein 150 in tethering protein phosphatase 2B to mediate nutrient-stimulated insulin secretion and thus modulate glucose homeostasis.
摘要
葡萄糖刺激的胰岛素分泌受多种蛋白磷酸化事件的控制，对于葡萄糖稳态的调节至关重要。蛋白激酶 A (PKA) 已知在β细胞生理学中发挥作用，但它的锚定蛋白的作用尚未完全了解。Hinke 等人 (2012) 说明了 A-激酶锚定蛋白 150 在固定蛋白磷酸酶 2B 以介导营养物质刺激的胰岛素分泌从而调节葡萄糖稳态方面的重要性。
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