School of Cancer Sciences, College of Medicine, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Curr Hematol Malig Rep. 2012 Dec;7(4):276-84. doi: 10.1007/s11899-012-0136-z.
The potent growth-transforming properties of Epstein-Barr virus (EBV) and its role in pathogenesis of a range of B cell and epithelial malignancies are well established. By contrast, the association of this B lymphotropic virus with malignancies of T and NK cell origin was entirely unexpected. Although a number of mature T and NK lymphoma subtypes have been associated with EBV, evidence for a robust viral/tumour relationship is principally limited to extranodal NK/T lymphoma (ENKTL). Despite progress in diagnosis and classification, alongside an evolving understanding of ENKTL pathobiology, EBV's contribution to lymphomagenesis remains largely unresolved. Challenges relate to the rarity of this entity, a lack of clinical and biological correlative data and scarcity of fresh tissue for molecular and functional studies. Nonetheless, recent studies on viral and cellular gene expression have permitted new avenues of investigation into ENKTL pathobiology aiming to extend our understanding of disease biology and ultimately improve clinical outcomes.
EBV 具有强大的转化生长特性，其在一系列 B 细胞和上皮恶性肿瘤的发病机制中起重要作用，这已得到充分证实。相比之下，这种 B 淋巴细胞病毒与 T 细胞和 NK 细胞来源的恶性肿瘤的关联完全出乎意料。尽管有许多成熟的 T 细胞和 NK 淋巴瘤亚型与 EBV 相关，但强有力的病毒/肿瘤相关性的证据主要仅限于结外 NK/T 淋巴瘤（ENKTL）。尽管在诊断和分类方面取得了进展，同时对 ENKTL 发病机制的认识也在不断发展，但 EBV 在淋巴瘤发生中的作用在很大程度上仍未得到解决。这些挑战涉及到该实体的罕见性、缺乏临床和生物学相关性数据以及缺乏用于分子和功能研究的新鲜组织。尽管如此，最近关于病毒和细胞基因表达的研究为 ENKTL 发病机制的新研究途径提供了可能，旨在扩展我们对疾病生物学的理解，并最终改善临床结果。
