Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.
J Infect Dis. 2012 Dec 1;206(11):1798-802. doi: 10.1093/infdis/jis596. Epub 2012 Sep 14.
Patients with sepsis in the intensive care unit (ICU) are prone to develop Candida infections. Here, we investigated Candida-induced T-helper 17 (Th17) responses during experimental human endotoxemia and in patients with sepsis admitted to the ICU. Peripheral blood mononuclear cells were stimulated with Candida albicans. The Th17 response was significantly lower during endotoxemia, compared with baseline. Patients with gram-negative sepsis had a significantly lower Th17 response as compared to healthy controls. These data demonstrate that the Th17 response is deficient during endotoxin-related systemic inflammation, which likely represents an important risk factor for increased susceptibility to develop Candida infection in patients with sepsis.
重症监护病房（ICU）中患有败血症的患者容易发生念珠菌感染。在这里，我们研究了实验性人体内毒素血症和 ICU 收治的败血症患者中念珠菌诱导的辅助性 T 细胞 17（Th17）反应。用白色念珠菌刺激外周血单核细胞。与基线相比，内毒素血症期间 Th17 反应明显降低。革兰氏阴性败血症患者的 Th17 反应明显低于健康对照组。这些数据表明，在与内毒素相关的全身炎症期间，Th17 反应不足，这可能是败血症患者易发生念珠菌感染的重要危险因素。
