Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Department of Nursing, Zhongshan Hospital, Fudan University, Shanghai, China.
Front Immunol. 2023 Feb 1;14:1113560. doi: 10.3389/fimmu.2023.1113560. eCollection 2023.
Kidney transplantation (KT) is an ultimate treatment of end-stage chronic kidney disease, which can meet a lot of complications induced by immune system. With under-controlled immunosuppression, the patient will obtain a good prognosis. Otherwise, allograft disfunction will cause severe organ failure and even immune collapse. Acute or chronic allograft dysfunction after KT is related to Th17, Treg, and Th17/Treg to a certain extent. Elevated Th17 levels may lead to acute rejection or chronic allograft dysfunction. Treg mainly plays a protective role on allografts by regulating immune response. The imbalance of the two may further aggravate the balance of immune response and damage the allograft. Controlling Th17 level, improving Treg function and level, and adjusting Th17/Treg ratio may have positive effects on longer allograft survival and better prognosis of receptors.
肾移植（KT）是治疗终末期慢性肾病的终极手段，可以解决免疫系统引起的许多并发症。如果免疫抑制控制得当，患者的预后会很好。否则，移植物功能障碍会导致严重的器官衰竭甚至免疫崩溃。KT 后急性或慢性移植物功能障碍与 Th17、Treg 以及 Th17/Treg 有一定的关系。Th17 水平升高可能导致急性排斥反应或慢性移植物功能障碍。Treg 通过调节免疫反应主要对移植物发挥保护作用。两者的失衡可能进一步加重免疫反应的失衡，损害移植物。控制 Th17 水平、改善 Treg 的功能和水平以及调节 Th17/Treg 比值可能对延长移植物的存活时间和受体的预后有积极作用。
