Herzmann Grit, Jin Mingwu, Cordes Dietmar, Curran Tim
Department of Psychology and Neuroscience, University of Colorado Boulder, USA.
Cogn Neurosci. 2012 Sep 1;3(3-4):174-192. doi: 10.1080/17588928.2012.669364. Epub 2012 Feb 27.
Despite a large body of recognition memory research, its temporal, measured with ERPs, and spatial, measured with fMRI, substrates have never been investigated in the same subjects. In the present study, we obtained this information in parallel sessions, in which subjects studied and recognized images of visual objects and their orientation. The results showed that ERP-familiarity processes between 240 and 440 ms temporally preceded recollection processes and were structurally associated with prefrontal brain regions. Recollection processes were most prominent from 440 to 600 ms and correlated with activation in temporal, parietal, and occipital brain regions. Post-retrieval monitoring, which occurred in the ERP between 600 and 1000 ms as a long-lasting slow-wave over frontal channel groups, showed correlations with activation in the prefrontal and parietal cortex. These ERP/fMRI relationships showed some correspondences to source localizations of the investigated ERP memory effects.
尽管已有大量关于识别记忆的研究，但从未在同一受试者中对其通过事件相关电位（ERP）测量的时间性底物和通过功能磁共振成像（fMRI）测量的空间性底物进行过研究。在本研究中，我们在平行实验环节中获取了这些信息，在这些环节中，受试者对视觉物体及其方向的图像进行学习和识别。结果表明，ERP所反映的240至440毫秒之间的熟悉度过程在时间上先于回忆过程，并且在结构上与前额叶脑区相关。回忆过程在440至600毫秒最为显著，并与颞叶、顶叶和枕叶脑区的激活相关。检索后监测在ERP中表现为600至1000毫秒之间额叶通道组上持续存在的慢波，与前额叶和顶叶皮层的激活相关。这些ERP/fMRI关系与所研究的ERP记忆效应的来源定位存在一些对应关系。
