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阐明了一种新的途径，通过该途径 HDAC1 通过表达 SOX-17 和 BMP2 来控制心肌细胞分化。

Elucidation of a novel pathway through which HDAC1 controls cardiomyocyte differentiation through expression of SOX-17 and BMP2.

机构信息

Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.

出版信息

PLoS One. 2012;7(9):e45046. doi: 10.1371/journal.pone.0045046. Epub 2012 Sep 12.

DOI:10.1371/journal.pone.0045046
PMID:22984607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3440419/
Abstract

Embryonic Stem Cells not only hold a lot of potential for use in regenerative medicine, but also provide an elegant and efficient way to study specific developmental processes and pathways in mammals when whole animal gene knock out experiments fail. We have investigated a pathway through which HDAC1 affects cardiovascular and more specifically cardiomyocyte differentiation in ES cells by controlling expression of SOX17 and BMP2 during early differentiation. This data explains current discrepancies in the role of HDAC1 in cardiovascular differentiation and sheds light into a new pathway through which ES cells determine cardiovascular cell fate.

摘要

胚胎干细胞不仅在再生医学中有很大的应用潜力，而且在全动物基因敲除实验失败时，为研究哺乳动物特定的发育过程和途径提供了一种优雅而有效的方法。我们研究了一条途径，即通过控制早期分化过程中 SOX17 和 BMP2 的表达，HDAC1 影响 ES 细胞中的心血管分化，更具体地说是心肌细胞分化。该数据解释了 HDAC1 在心血管分化中的作用目前存在的差异，并为 ES 细胞决定心血管细胞命运的新途径提供了线索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dfd/3440419/7b6e40328b8c/pone.0045046.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dfd/3440419/249682a06c27/pone.0045046.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dfd/3440419/45196b8ab176/pone.0045046.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dfd/3440419/6560bbde8cc2/pone.0045046.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dfd/3440419/cd5af4ac691d/pone.0045046.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dfd/3440419/7b6e40328b8c/pone.0045046.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dfd/3440419/249682a06c27/pone.0045046.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dfd/3440419/45196b8ab176/pone.0045046.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dfd/3440419/6560bbde8cc2/pone.0045046.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dfd/3440419/cd5af4ac691d/pone.0045046.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dfd/3440419/7b6e40328b8c/pone.0045046.g005.jpg

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