Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin, Heilongjiang Province, 150081, People's Republic of China.
Department of Internal Diseases, Bashkir State Medical University, Ufa, Russia.
Stem Cell Res Ther. 2018 Feb 26;9(1):44. doi: 10.1186/s13287-018-0773-9.
In the past years, cardiac mortality has decreased, but cardiac diseases are still responsible for millions of deaths every year worldwide. Bone-marrow mesenchymal stem cells (BMSCs) transplantation may be a promising therapeutic strategy because of its capacity to differentiate into cardiac cells. Current research indicates that chemical substances, microRNAs, and cytokines have biological functions that regulate the cardiomyocytes differentiation of BMSCs. In this review, we chiefly summarize the regulatory factors that induce BMSCs to differentiate into cardiomyocytes.
在过去的几年中，心脏死亡率有所下降，但心脏病仍然每年导致全球数百万人死亡。骨髓间充质干细胞（BMSCs）移植可能是一种很有前途的治疗策略，因为它能够分化为心脏细胞。目前的研究表明，化学物质、microRNAs 和细胞因子具有调节 BMSCs 向心肌细胞分化的生物学功能。在这篇综述中，我们主要总结了诱导 BMSCs 分化为心肌细胞的调节因子。
