• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Drug Repurposing for Cancer Therapy.

作者信息

Telleria Carlos M

机构信息

Division of Basic Biomedical Sciences, Sanford School of Medicine of The University of South Dakota, 414 East Clark Street, Vermillion, SD 57069.

出版信息

J Cancer Sci Ther. 2012 Jul 21;4(7):ix-xi. doi: 10.4172/1948-5956.1000e108.

DOI:10.4172/1948-5956.1000e108
PMID:22984635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3440183/
Abstract
摘要

相似文献

1
Drug Repurposing for Cancer Therapy.用于癌症治疗的药物重新利用。
J Cancer Sci Ther. 2012 Jul 21;4(7):ix-xi. doi: 10.4172/1948-5956.1000e108.
2
Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining.通过基于L1000的综合连通性图谱数据库挖掘进行系统性多药理学和药物再利用。
R Soc Open Sci. 2018 Nov 28;5(11):181321. doi: 10.1098/rsos.181321. eCollection 2018 Nov.
3
DeCoST: A New Approach in Drug Repurposing From Control System Theory.DeCoST:一种源自控制系统理论的药物再利用新方法。
Front Pharmacol. 2018 Jun 5;9:583. doi: 10.3389/fphar.2018.00583. eCollection 2018.
4
Discovery of Noncancer Drug Effects on Survival in Electronic Health Records of Patients With Cancer: A New Paradigm for Drug Repurposing.在癌症患者电子健康记录中发现非癌症药物对生存的影响:药物重新利用的新范例
JCO Clin Cancer Inform. 2019 May;3:1-9. doi: 10.1200/CCI.19.00001.
5
Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing.青蒿素类药物作为一种新型抗癌疗法:通过药物再利用靶向全球癌症大流行。
Pharmacol Ther. 2020 Dec;216:107706. doi: 10.1016/j.pharmthera.2020.107706. Epub 2020 Oct 16.
6
Drug Repurposing Approaches to Combating Viral Infections.对抗病毒感染的药物重新利用方法。
J Clin Med. 2020 Nov 23;9(11):3777. doi: 10.3390/jcm9113777.
7
Repurposing Drugs for Skin Cancer.重新利用药物治疗皮肤癌。
Curr Med Chem. 2020;27(42):7214-7221. doi: 10.2174/0929867327666191220103901.
8
Challenges and perspective of drug repurposing strategies in early phase clinical trials.早期临床试验中药物重新利用策略的挑战与前景
Oncoscience. 2015 Jun 30;2(6):576-80. doi: 10.18632/oncoscience.173. eCollection 2015.
9
Drug Repurposing in Anticancer Reagent Development.抗癌试剂开发中的药物重新利用。
Comb Chem High Throughput Screen. 2017;20(5):395-402. doi: 10.2174/1386207319666161226143424.
10
Recent Drug-Repurposing-Driven Advances in the Discovery of Novel Antibiotics.近期药物重定位驱动的新型抗生素发现进展。
Curr Med Chem. 2019;26(28):5363-5388. doi: 10.2174/0929867325666180706101404.

引用本文的文献

1
Chemosensitizer Effects of Cisplatin- and 5-Fluorouracil-Treated Hepatocellular Carcinomas by Lidocaine.利多卡因对顺铂和5-氟尿嘧啶治疗的肝细胞癌的化学增敏作用
Int J Mol Sci. 2025 Jul 24;26(15):7137. doi: 10.3390/ijms26157137.
2
Auranofin Induces Lethality Driven by Reactive Oxygen Species in High-Grade Serous Ovarian Cancer Cells.金诺芬通过活性氧诱导高级别浆液性卵巢癌细胞的致死性。
Cancers (Basel). 2023 Oct 25;15(21):5136. doi: 10.3390/cancers15215136.
3
Evaluating Ligand Modifications of the Titanocene and Auranofin Moieties for the Development of More Potent Anticancer Drugs.评估二茂钛和金诺芬部分的配体修饰以开发更有效的抗癌药物。
Inorganics (Basel). 2020 Feb;8(2). doi: 10.3390/inorganics8020010. Epub 2020 Jan 26.
4
Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy.铁和铜细胞内螯合作为一种抗癌药物策略
Inorganics (Basel). 2018;6(4). doi: 10.3390/inorganics6040126. Epub 2018 Nov 30.
5
Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis.硝唑尼特在 SARS-CoV-2 治疗或化学预防中的再利用的剂量预测。
Br J Clin Pharmacol. 2021 Apr;87(4):2078-2088. doi: 10.1111/bcp.14619. Epub 2020 Dec 1.
6
The effects of growth hormone on therapy resistance in cancer.生长激素对癌症治疗耐药性的影响。
Cancer Drug Resist. 2019 Summer;2(3):827-846. doi: 10.20517/cdr.2019.27. Epub 2019 Sep 19.
7
Phosphorylated STAT3 (Tyr705) as a biomarker of response to pimozide treatment in triple-negative breast cancer.磷酸化STAT3(Tyr705)作为三阴性乳腺癌中对匹莫齐特治疗反应的生物标志物。
Cancer Biol Ther. 2020 Jun 2;21(6):506-521. doi: 10.1080/15384047.2020.1726718. Epub 2020 Mar 13.
8
Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells.苯并咪唑类药物下调 Mdm2 和 MdmX 并激活 MdmX 过表达肿瘤细胞中的 p53。
Molecules. 2019 Jun 7;24(11):2152. doi: 10.3390/molecules24112152.
9
Giving Drugs a Second Chance: Overcoming Regulatory and Financial Hurdles in Repurposing Approved Drugs As Cancer Therapeutics.给药物第二次机会:克服将已批准药物重新用作癌症治疗药物过程中的监管和资金障碍。
Front Oncol. 2017 Nov 14;7:273. doi: 10.3389/fonc.2017.00273. eCollection 2017.
10
A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening.采用机器学习、抑制剂设计和高通量筛选方法系统地鉴定新型癌症药物靶点。
Genome Med. 2014 Jul 30;6(7):57. doi: 10.1186/s13073-014-0057-7. eCollection 2014.

本文引用的文献

1
Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells.二甲双胍能杀死癌细胞并使癌细胞对放疗更敏感,而且能优先杀死肿瘤干细胞。
Sci Rep. 2012;2:362. doi: 10.1038/srep00362. Epub 2012 Apr 12.
2
Repurposing approved and abandoned drugs for the treatment and prevention of cancer through public-private partnership.通过公私合作,将已获批和废弃药物重新用于癌症的治疗和预防。
Cancer Res. 2012 Mar 1;72(5):1055-8. doi: 10.1158/0008-5472.CAN-11-3439. Epub 2012 Jan 13.
3
Reengineering translational science: the time is right.重新设计转化科学:时机已到。
Sci Transl Med. 2011 Jul 6;3(90):90cm17. doi: 10.1126/scitranslmed.3002747.
4
Biomedicine. NIH's secondhand shop for tried-and-tested drugs.
Science. 2011 Jun 24;332(6037):1492. doi: 10.1126/science.332.6037.1492.
5
Antiprogestin mifepristone inhibits the growth of cancer cells of reproductive and non-reproductive origin regardless of progesterone receptor expression.抗孕激素米非司酮抑制孕激素受体表达与否的生殖和非生殖来源的癌细胞生长。
BMC Cancer. 2011 May 27;11:207. doi: 10.1186/1471-2407-11-207.
6
Growth inhibition induced by antiprogestins RU-38486, ORG-31710, and CDB-2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2.抗孕激素 RU-38486、ORG-31710 和 CDB-2914 诱导卵巢癌细胞生长抑制涉及细胞周期蛋白依赖性激酶 2 的抑制。
Invest New Drugs. 2012 Jun;30(3):967-80. doi: 10.1007/s10637-011-9655-z. Epub 2011 Mar 22.
7
Resistance to cisplatin does not affect sensitivity of human ovarian cancer cell lines to mifepristone cytotoxicity.对顺铂的耐药性并不影响人卵巢癌细胞系对米非司酮细胞毒性的敏感性。
Cancer Cell Int. 2009 Feb 17;9:4. doi: 10.1186/1475-2867-9-4.
8
Mifepristone abrogates repopulation of ovarian cancer cells in between courses of cisplatin treatment.米非司酮可消除顺铂治疗疗程之间卵巢癌细胞的再增殖。
Int J Oncol. 2009 Mar;34(3):743-55. doi: 10.3892/ijo_00000200.
9
Selective progesterone receptor modulators 3: use in oncology, endocrinology and psychiatry.选择性孕激素受体调节剂3:在肿瘤学、内分泌学和精神病学中的应用
Expert Opin Pharmacother. 2008 Oct;9(14):2487-96. doi: 10.1517/14656566.9.14.2487.
10
Selective progesterone receptor modulators 2: use in reproductive medicine.选择性孕激素受体调节剂2:在生殖医学中的应用
Expert Opin Pharmacother. 2008 Oct;9(14):2473-85. doi: 10.1517/14656566.9.14.2473.