用于恒速蛋白质输送的纳米结构薄膜聚合物器件。
Nanostructured thin film polymer devices for constant-rate protein delivery.
机构信息
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94158, USA.
出版信息
Nano Lett. 2012 Oct 10;12(10):5355-61. doi: 10.1021/nl302747y. Epub 2012 Sep 19.
Abstract
Herein long-term delivery of proteins from biodegradable thin film devices is demonstrated, where a nanostructured polymer membrane controls release. Protein was sealed between two poly(caprolactone) films, which generated the thin film devices. Protein release for 210 days was shown in vitro, and stable activity was established through 70 days with a model protein. These thin film devices present a promising delivery platform for biologic therapeutics, particularly for application in constrained spaces.
摘要
本文展示了可生物降解薄膜装置中蛋白质的长期输送，其中纳米结构聚合物膜控制释放。蛋白质被密封在两个聚己内酯薄膜之间，形成了薄膜装置。在体外进行了 210 天的蛋白质释放，通过模型蛋白质建立了 70 天的稳定活性。这些薄膜装置为生物治疗药物提供了一种有前途的输送平台，特别是在受限空间中的应用。
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