Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA.
UC Berkeley-UCSF Graduate Program in Bioengineering, San Francisco, CA 94158, USA.
Cell Stem Cell. 2022 May 5;29(5):692-721. doi: 10.1016/j.stem.2022.04.002. Epub 2022 Apr 27.
The successful transplantation of stem cells has the potential to transform regenerative medicine approaches and open promising avenues to repair, replace, and regenerate diseased, damaged, or aged tissues. However, pre-/post-transplantation issues of poor cell survival, retention, cell fate regulation, and insufficient integration with host tissues constitute significant challenges. The success of stem cell transplantation depends upon the coordinated sequence of stem cell renewal, specific lineage differentiation, assembly, and maintenance of long-term function. Advances in biomaterials can improve pre-/post-transplantation outcomes by integrating biophysiochemical cues and emulating tissue microenvironments. This review highlights leading biomaterials-based approaches for enhancing stem cell transplantation.
干细胞的成功移植具有改变再生医学方法的潜力，并为修复、替代和再生患病、受损或衰老的组织开辟有希望的途径。然而，移植前后细胞存活率低、保留率低、细胞命运调控以及与宿主组织的整合不足等问题仍然是重大挑战。干细胞移植的成功取决于干细胞的更新、特定谱系分化、组装和长期功能维持的协调顺序。生物材料的进步可以通过整合生物物理化学线索和模拟组织微环境来改善移植前后的结果。本文重点介绍了基于生物材料的几种主要方法，以增强干细胞的移植效果。
