National Institute of Science Education and Research, Institute of Physics Campus, Sainik School, Sachivalaya marg, Bhubaneswar-751005, India.
J Control Release. 2012 Feb 28;158(1):15-33. doi: 10.1016/j.jconrel.2011.09.064. Epub 2011 Sep 21.
Biodegradable polymer based novel drug delivery systems have provided many avenues to improve therapeutic efficacy and pharmacokinetic parameters of medicinal entities. Among synthetic biodegradable polymer, poly-є-caprolactone (PCL) is a polymer with very low glass transition temperature and melting point. Owing to its amicable nature and tailorable properties it has been trialed in almost all novel drug delivery systems and tissue engineering application in use/investigated so far. This review aims to provide an up to date of drugs incorporated in different PCL based formulations, their purpose and brief outcomes. Demonstrated PCL formulations with or without drugs, intended for drug delivery and/or tissue engineering application such as microsphere, nanoparticles, scaffolds, films, fibers, micelles etc. are categorized based on method of preparation.
基于可生物降解聚合物的新型药物传递系统为提高药物实体的治疗效果和药代动力学参数提供了多种途径。在合成可生物降解聚合物中，聚己内酯（PCL）是一种玻璃化转变温度和熔点非常低的聚合物。由于其友好的性质和可定制的特性，它已经在迄今为止几乎所有新型药物传递系统和组织工程应用中进行了试验。本综述旨在提供不同 PCL 制剂中包含的药物的最新信息，包括它们的用途和简要结果。根据制备方法对载药或未载药的 PCL 制剂进行分类，这些制剂旨在用于药物传递和/或组织工程应用，如微球、纳米粒、支架、薄膜、纤维、胶束等。
Zotero 插件