Lu Yongping, Chen Youpeng, Xiao Xiaomin, Liang Xujing, Li Jian, Huang Simin, Chen Xin, Hocher Berthold
Department of Infectious Diseases, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2012 Sep;32(9):1369-72.
To explore the impact of maternal hepatitis B surface antigen (HBsAg) carrier status on the occurrence of preterm birth.
We analyzed pregnancy-related complications, outcomes and fetal growth index in 188 HBsAg positive singleton pregnant women during the period of May 2009 to July 2011, with 265 HBsAg-negative women with singleton pregnancies in the same period serving as controls.
The HBsAg-positive pregnant women showed a significantly higher incidence of placenta praevia than the control group (2.66% vs 0%, P=0.03), and the incidence of preterm delivery (<37 weeks) was also significantly higher in HBsAg-positive group (12.23% vs 6.04%, P=0.02). The incidences of gestational hypertension, preeclampsia, gestational diabetes mellitus, abnormal glucose tolerance, premature rupture of membranes, cesarean delivery, and postpartum hemorrhage showed no significant differences between the two groups (P>0.05), nor did the fetal birth weight, height, head circumference or Apgar scores at 1, 5, and 10 min (P>0.05). Logistic regression identified HBsAg positivity, abnormal ALT, placenta praevia, and severe preeclampsia as the risk factors for preterm delivery.
HBsAg carrier status can increase the risk of preterm delivery in pregnancy, but it does not seem to affect the fetal growth.
探讨母亲乙肝表面抗原（HBsAg）携带状态对早产发生情况的影响。
我们分析了2009年5月至2011年7月期间188名单胎HBsAg阳性孕妇的妊娠相关并发症、结局及胎儿生长指标，并将同期265名单胎HBsAg阴性孕妇作为对照。
HBsAg阳性孕妇前置胎盘的发生率显著高于对照组（2.66% 对0%，P = 0.03），HBsAg阳性组早产（<37周）发生率也显著更高（12.23% 对6.04%，P = 0.02）。两组间妊娠期高血压、子痫前期、妊娠期糖尿病、糖耐量异常、胎膜早破、剖宫产及产后出血的发生率无显著差异（P > 0.05），胎儿出生体重、身高、头围及1、5、10分钟时的阿氏评分也无显著差异（P > 0.05）。Logistic回归分析确定HBsAg阳性、谷丙转氨酶异常、前置胎盘及重度子痫前期为早产的危险因素。
HBsAg携带状态可增加孕期早产风险，但似乎不影响胎儿生长。
