Keramat Afsaneh, Younesian Masud, Gholami Fesharaki Mohammad, Hasani Maryam, Mirzaei Samaneh, Ebrahimi Elham, Alavian Seyed Moaed, Mohammadi Fatemeh
Dept. of Reproductive Health, Student Research Committee, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran.
Dept. of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Public Health. 2017 Apr;46(4):468-474.
We aimed to explore whether maternal asymptomatic hepatitis B (HB) infection effects on pre-term rupture of membranous (PROM), stillbirth, preeclampsia, eclampsia, gestational hypertension, or antepartum hemorrhage.
We searched the PubMed, Scopus, and ISI web of science from 1990 to Feb 2015. In addition, electronic literature searches supplemented by searching the gray literature (e.g., conference abstracts thesis and the result of technical reports) and scanning the reference lists of included studies and relevant systematic reviews. We explored statistical heterogeneity using the, I2 and tau-squared (Tau2) statistical tests.
Eighteen studies were included. Preterm rupture of membranous (PROM), stillbirth, preeclampsia, eclampsia, gestational hypertension and antepartum hemorrhage were considerable outcomes in this survey. The results showed no significant association between inactive HB and these complications in pregnancy. The small amounts of -value and chi-square and large amount of I2 suggested the probable heterogeneity in this part, which we tried to modify with statistical methods such as subgroup analysis.
Inactive HB infection did not increase the risk of adversely mentioned outcomes in this study. Further, well-designed studies should be performed to confirm the results.
我们旨在探讨母亲无症状乙型肝炎（HB）感染是否会对胎膜早破（PROM）、死产、先兆子痫、子痫、妊娠期高血压或产前出血产生影响。
我们检索了1990年至2015年2月期间的PubMed、Scopus和科学网ISI。此外，通过检索灰色文献（如会议摘要、论文和技术报告结果）以及浏览纳入研究和相关系统评价的参考文献列表来补充电子文献检索。我们使用I2和tau平方（Tau2）统计检验来探讨统计异质性。
纳入了18项研究。胎膜早破（PROM）、死产、先兆子痫、子痫、妊娠期高血压和产前出血是本次调查中的重要结果。结果显示，非活动性HB与这些妊娠并发症之间无显著关联。少量的P值和卡方值以及大量的I2表明这部分可能存在异质性，我们试图通过亚组分析等统计方法进行修正。
在本研究中，非活动性HB感染并未增加上述不良结局的风险。此外，应开展设计良好的研究以证实这些结果。
