Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Semin Radiat Oncol. 2012 Oct;22(4):311-20. doi: 10.1016/j.semradonc.2012.05.008.
Gastrointestinal malignancies are generally considered diseases that affect older patients, with a peak in incidence in the sixth and seventh decades. Age has often been a surrogate to screen patients who may have more difficulty in tolerating treatment and the related side effects; however, chronologic age does not necessarily correlate with physiological organ impairment or poor performance status, both of which can vary substantially between individuals. Therefore, the assessment of candidacy for the ability to tolerate optimal cancer treatment should focus on the assessment of the extent of comorbidity and functional status. The review aims at providing a broad overview of the published literature regarding the tolerability and efficacy of standard treatment approaches for the most common gastrointestinal malignancies, including esophageal, pancreatic, and colorectal cancer, among elderly patients.
胃肠道恶性肿瘤通常被认为是影响老年患者的疾病，发病率在第六和第七个十年达到高峰。年龄常常是筛选可能更难以耐受治疗和相关副作用的患者的替代指标；然而，生理器官损伤或较差的身体状况并不一定与年龄相关，这些在个体之间差异很大。因此，评估患者是否有能力耐受最佳癌症治疗的能力应侧重于评估合并症的严重程度和功能状态。本综述旨在提供关于老年患者中最常见的胃肠道恶性肿瘤（包括食管癌、胰腺癌和结直肠癌）的标准治疗方法的耐受性和疗效的已发表文献的广泛概述。
