维生素 D 与药物代谢酶 CYP3A4 之间的相互作用。
Interplay between vitamin D and the drug metabolizing enzyme CYP3A4.
机构信息
Department of Pharmaceutics, University of Washington, Seattle, WA 98195,, United States.
出版信息
J Steroid Biochem Mol Biol. 2013 Jul;136:54-8. doi: 10.1016/j.jsbmb.2012.09.012. Epub 2012 Sep 15.
Abstract
Cytochrome P450 3A4 (CYP3A4) is a multifunctional enzyme involved in both xenobiotic and endobiotic metabolism. This review focuses on two aspects: regulation of CYP3A4 expression by vitamin D and metabolism of vitamin D by CYP3A4. Enterohepatic circulation of vitamin D metabolites and their conjugates will be also discussed. The interplay between vitamin D and CYP3A4 provides new insights into our understanding of how enzyme induction can contribute to vitamin D deficiency. This article is part of a Special Issue entitled 'Vitamin D Workshop'.
摘要
细胞色素 P450 3A4（CYP3A4）是一种多功能酶，参与外源性和内源性代谢。本文重点介绍两个方面：维生素 D 对 CYP3A4 表达的调节和 CYP3A4 对维生素 D 的代谢。还将讨论维生素 D 代谢产物及其缀合物的肠肝循环。维生素 D 和 CYP3A4 之间的相互作用为我们理解酶诱导如何导致维生素 D 缺乏提供了新的认识。本文是题为“维生素 D 研讨会”的特刊的一部分。
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