Libert Cédric, Graille Mélanie, Nicolier Alexandra
Parc Zoologique de Montpellier, 50 avenue Agropolis, 34090 Montpellier, France.
J Vet Med Sci. 2013 Feb;75(2):183-5. doi: 10.1292/jvms.12-0229. Epub 2012 Sep 14.
A 10-year-old male fossa (Crytoprocta ferox) exhibited clinical signs of diarrhea, anorexia and weight loss. Chemistry values and echographic results were suggestive of intestinal lymphoma. Postmortem examination revealed severe multifocal wall thickening of the small intestine with severe enlargement of the pancreatic lymph node. Microscopically, the small intestine was multifocally transmurally infiltrated by large neoplastic round cells also found in the pancreatic lymph node and the liver. On immunohistochemistry, the neoplastic cells stained intensely with CD3 and didn't stain with CD79a. Based on these findings, a diagnosis of intestinal T-cell lymphoma with pancreatic lymph node and liver involvement was made. To the authors' knowledge, this is the first report of a lymphoma with immunohistochemical phenotyping in a fossa.
一只10岁雄性马岛獴(Cryptoprocta ferox)出现腹泻、厌食和体重减轻的临床症状。血液生化指标和超声检查结果提示为肠道淋巴瘤。尸检发现小肠严重多灶性壁增厚,胰腺淋巴结严重肿大。显微镜下,小肠多灶性全层被大的肿瘤性圆形细胞浸润,这些细胞在胰腺淋巴结和肝脏中也有发现。免疫组化显示,肿瘤细胞CD3染色强阳性,CD79a染色阴性。基于这些发现,诊断为累及胰腺淋巴结和肝脏的肠道T细胞淋巴瘤。据作者所知,这是首例对马岛獴淋巴瘤进行免疫组化表型分析的报道。