重设计的表鬼臼毒素。
Reengineered epipodophyllotoxin.
机构信息
Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, New Mexico 87801, USA.
出版信息
Chem Commun (Camb). 2012 Oct 28;48(84):10416-8. doi: 10.1039/c2cc35044k. Epub 2012 Sep 17.
Abstract
A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.
摘要
合成了表鬼臼毒素的变体结构骨架，并发现其在抗增殖和微管去稳定化特性方面可与天然环木菠萝烷媲美。这一发现为微管蛋白靶向药物开辟了一个新的结构类别。
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