Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.
Dermatology. 2012;225(1):88-92. doi: 10.1159/000341534. Epub 2012 Sep 11.
Psoriasis is associated with an increased cardiovascular risk. Circulating endothelial progenitor cells (CEPCs) play a significant role in the maintenance of vascular homeostasis.
The aim of this study was to evaluate the number of CEPCs in patients with psoriasis compared to controls and assess possible correlations between the number of these cells and the plasma levels of vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and clinical features of psoriasis.
The number of CEPCs, identified as CD133+/KDR+ cells, was determined with flow cytometry in peripheral blood of psoriatic patients (n = 63) and controls (n = 31). The plasma levels of VEGF and sVEGFR-1 were measured with enzyme-linked immunosorbent assay.
The number of CEPCs was significantly reduced in psoriatic patients compared with controls (p = 0.000026) and inversely correlated with disease severity (R = -0.283; p = 0.0248).
A reduced number of CEPCs may contribute to endothelial dysfunction in patients with psoriasis.
银屑病与心血管风险增加有关。循环内皮祖细胞（CEPCs）在维持血管稳态方面发挥着重要作用。
本研究旨在评估银屑病患者与对照组之间 CEPCs 的数量，并评估这些细胞的数量与血管内皮生长因子（VEGF）、可溶性血管内皮生长因子受体-1（sVEGFR-1）的血浆水平以及银屑病的临床特征之间的可能相关性。
采用流式细胞术测定外周血中银屑病患者（n=63）和对照组（n=31）的 CEPCs 数量，其鉴定为 CD133+/KDR+细胞。采用酶联免疫吸附试验测定 VEGF 和 sVEGFR-1 的血浆水平。
与对照组相比，银屑病患者的 CEPCs 数量显著减少（p=0.000026），且与疾病严重程度呈负相关（R=-0.283；p=0.0248）。
CEPCs 数量减少可能导致银屑病患者的内皮功能障碍。
