多发性硬化症中的疾病机制：钾离子通道 KIR4.1——多发性硬化症中的一个潜在自身抗原。
Disease mechanisms in MS: the potassium channel KIR4.1--a potential autoantigen in MS.
机构信息
Department of Neurology, Ohio State University, Columbus, OH 43210, USA.
出版信息
Nat Rev Neurol. 2012 Nov 5;8(11):595-6. doi: 10.1038/nrneurol.2012.193.
PMID:22986435
Abstract
Multiple sclerosis is an inflammatory, demyelinating disease in which antigens of the myelin sheath have been considered the autoimmune target. A recent study suggests that the potassium channel KIR4.1 is another potential autoantigen in some patients with multiple sclerosis, and might also be a target in other demyelinating diseases.
摘要
多发性硬化症是一种炎症性脱髓鞘疾病，其中髓鞘的抗原被认为是自身免疫的靶标。最近的一项研究表明，钾通道 KIR4.1 是一些多发性硬化症患者的另一个潜在自身抗原，也可能是其他脱髓鞘疾病的靶标。
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