Yang Zengyue, Lv Yajie, Lv Yali, Wang Yong
Department of Urinary Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Urol Int. 2012;89(3):337-41. doi: 10.1159/000341701. Epub 2012 Sep 14.
There is no consensus on the association between the tumor necrosis factor-α (TNF-α) gene promoter -308 A/G single nucleotide polymorphisms and bladder cancer risk. To obtain a more precise estimation of this correlation, we conducted a meta-analysis. The PubMed, MEDLINE, Cochrane Library and China National Knowledge Infrastructure (CNKI) databases were searched for relevant published studies. Seven case-control studies with a total of 1,311 cases and 1,436 controls were identified and analyzed. A notable correlation was observed between the TNF-α genotype and bladder cancer grade (AA+GA vs. GG; odds ratio 1.96, 95% confidence interval 1.37-2.80, p = 0.0002). In summary, this meta-analysis demonstrates that the TNF-α -308 AA+GA genotype may be a marker to the tumor-invasive stage of bladder cancer.
肿瘤坏死因子-α（TNF-α）基因启动子-308 A/G单核苷酸多态性与膀胱癌风险之间的关联尚无定论。为了更精确地评估这种相关性，我们进行了一项荟萃分析。检索了PubMed、MEDLINE、Cochrane图书馆和中国知网（CNKI）数据库中的相关已发表研究。确定并分析了7项病例对照研究，共1311例病例和1436例对照。观察到TNF-α基因型与膀胱癌分级之间存在显著相关性（AA+GA与GG相比；优势比1.96，95%置信区间1.37-2.80，p = 0.0002）。总之，这项荟萃分析表明，TNF-α -308 AA+GA基因型可能是膀胱癌肿瘤侵袭阶段的一个标志物。
