Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112 , USA.
Am J Nephrol. 2012;36(4):297-304. doi: 10.1159/000342330. Epub 2012 Sep 13.
BACKGROUND/AIMS: Plasma fluorescent oxidation products (FLOP) constitute a stable and easily measured biomarker of cumulative oxidative stress. However, their association with chronic kidney disease (CKD) has not been studied.
We examined the association of FLOP and CKD in 201 CKD patients and 201 controls without CKD from the community. CKD was defined as an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2) or the presence of albuminuria.
Adjusted median (interquartile range) FLOP levels were significantly higher in patients with CKD than in controls [FLOP1 (lipid oxidation products): 215.2 (181.3-268.7) vs. 156.6 (139.6-177.3) fluorescent intensity units/ml, p < 0.0001; FLOP2 (DNA oxidation products): 534.8 (379.3-842.4) vs. 269.9 (232.4-410.5) fluorescent intensity units/ml, p < 0.0001; FLOP3 (protein and phospholipid oxidation products): 51.4 (44.4-66.0) vs. 45.2 (38.3-51.7) fluorescent intensity units/ml, p = 0.002]. Compared with those with a FLOP level below the 75th percentile, participants with a FLOP level above the 75th percentile had increased odds of CKD after adjustment for covariables (FLOP1: odds ratio 13.1, 95% confidence interval 6.2-27.6; FLOP2: odds ratio 5.7, 95% confidence interval 2.9-11.1; FLOP3: odds ratio 2.4, 95% confidence interval 1.2-4.7). Levels of FLOP1, FLOP2 and FLOP3 were related to eGFR (p < 0.0001 for all) and log-transformed urine albumin (p < 0.005 for all) in multivariable-adjusted linear regression models.
These data indicate that an elevated FLOP level is associated with CKD status and severity. Future studies are warranted to elucidate its role in the development and progression of CKD.
背景/目的：血浆荧光氧化产物（FLOP）是一种稳定且易于测量的累积氧化应激生物标志物。然而，其与慢性肾脏病（CKD）的关系尚未得到研究。
我们检测了 201 例 CKD 患者和 201 例社区无 CKD 对照者的 FLOP 与 CKD 的关系。CKD 的定义为估算肾小球滤过率（eGFR）<60 ml/min/1.73 m2或白蛋白尿。
调整后的中位（四分位间距）FLOP 水平在 CKD 患者中明显高于对照组[FLOP1（脂质氧化产物）：215.2（181.3-268.7）比 156.6（139.6-177.3）荧光强度单位/ml，p<0.0001；FLOP2（DNA 氧化产物）：534.8（379.3-842.4）比 269.9（232.4-410.5）荧光强度单位/ml，p<0.0001；FLOP3（蛋白质和磷脂氧化产物）：51.4（44.4-66.0）比 45.2（38.3-51.7）荧光强度单位/ml，p=0.002]。与 FLOP 水平低于第 75 百分位的患者相比，调整协变量后，FLOP 水平高于第 75 百分位的患者 CKD 的比值比增加（FLOP1：比值比 13.1，95%置信区间 6.2-27.6；FLOP2：比值比 5.7，95%置信区间 2.9-11.1；FLOP3：比值比 2.4，95%置信区间 1.2-4.7）。FLOP1、FLOP2 和 FLOP3 水平与 eGFR（所有 p<0.0001）和尿白蛋白的对数值（所有 p<0.005）在多变量调整线性回归模型中相关。
这些数据表明，升高的 FLOP 水平与 CKD 状态和严重程度相关。需要进一步的研究来阐明其在 CKD 发生和进展中的作用。
