Biobanking Group, Branch of Institute of Biomedical Chemistry "Scientific and Education Center", 109028 Moscow, Russia.
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Russia.
Int J Mol Sci. 2021 Nov 2;22(21):11879. doi: 10.3390/ijms222111879.
Proteins expressed during the cell cycle determine cell function, topology, and responses to environmental influences. The development and improvement of experimental methods in the field of structural biology provide valuable information about the structure and functions of individual proteins. This work is devoted to the study of supersecondary structures of proteins and determination of their structural motifs, description of experimental methods for their detection, databases, and repositories for storage, as well as methods of molecular dynamics research. The interest in the study of supersecondary structures in proteins is due to their autonomous stability outside the protein globule, which makes it possible to study folding processes, conformational changes in protein isoforms, and aberrant proteins with high productivity.
在细胞周期中表达的蛋白质决定了细胞的功能、拓扑结构和对环境影响的反应。结构生物学领域实验方法的发展和改进为研究单个蛋白质的结构和功能提供了有价值的信息。这项工作致力于研究蛋白质的超二级结构，并确定其结构基序，描述检测它们的实验方法、数据库和存储库，以及分子动力学研究方法。人们对蛋白质中超二级结构的研究兴趣源于其在蛋白质球外的自主稳定性，这使得研究折叠过程、蛋白质同工型的构象变化以及具有高生产力的异常蛋白质成为可能。
